Publications

Selected Papers (‡co-first author)

1. Do Hoon Kwon‡, Feng Zhang‡, Brett A. McCray, Meha Kumar, Jeremy M. Sullivan, Charlotte J. Sumner, Seok-Yong Lee, “TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.” Nat. Commun.,2023. Jun 23;14(1):3732
   
   

2. Do Hoon Kwon, Feng Zhang, Justin G. Fedor, Yang Suo, Seok-Yong Lee, “Vanilloid-dependent conformational trajectory of TRPV1 opening revealed through cryoEM ensembles.” Nat. Commun. 2022 May 24;13(1):2874 

3. Do Hoon Kwon, Feng Zhang, Yang Suo, Jonathan Bouvette, Mario J. Borgnia, Seok-Yong Lee, “Heat-dependent opening of TRPV1 in the presence of capsaicin.” Nat. Struct. & Mol. Biol., 2021 Jul;28(7):554-563. PMID:34239123 (cover article)
   *This work was described in the 2021 Nobel Prize Medicine website (reference #29)
   https://www.nobelprize.org/prizes/medicine/2021/advanced-information/
   
   

4. Do Hoon Kwon, Ok Hyun Park, Leehyeon Kim, Yang Ouk Jung, Yeonkyoung Park, Hyeongseop Jeong, Jaekyung Hyun, Yoon Ki Kim, Hyun Kyu Song, “Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.” Nat. Commun., 2018 Aug;17(9):3291. PMID: 30120248
   
   

5. Do Hoon Kwon‡, Sulhee Kim‡, Yang Ouk Jung, Kyung-Hye Roh, Leehyeon Kim, Byeong-Won Kim, Seung Beom Hong, In Young Lee, Ju Han Song, Woo Cheol Lee, Eui-Ju Choi, Kwang Yeon Hwang, Hyun Kyu Song, “The 1:2 complex between RavZ and LC3 reveals a mechanism for deconjugation of LC3 on the phagophore membrane.”Autophagy, 2017 Jan;13(1):70-81. PMID: 27791457

Other Papers 

1. 1. Sarah H. Berth, Linh Vo, Do Hoon Kwon, Yasmine S. Damayanti, Gage Kosmanopoulos, Andrew Fox, Alexander R. Lau, Patrice Carr, Jack Donohue, Maya Hoke, Simone Thomas, Tiffany Grider, Karim Chafic, Thomas O. Crawford, Rachelle Gaudet, Michael E. Shy, Ute Hellmich, Seok-Yong Lee, Charlotte J. Sumner, Brett A. McCray. “Combined clinical, structural and cellular studies discriminate pathogenic and benign TRPV4 variants.” Brain, 2025 Feb;148:564-579. PMID: 39021275
      
      

   2. Gyeongseo Suk, Do Hoon Kwon, Axel Roers, Soman N Abraham, Hae Woong Choi, “Stabilization of activated mast cells by ORAI1 inhibitor suppresses peanut-induced anaphylaxis and acute diarrhea.” Pharmacol Res.,2023 Oct;196:106887. PMID: 37574155

1. 3. Han Kyu Lee, Do Hoon Kwon, David L Aylor, Douglas A Marchuk, “A cross-species approach using an in vivo evaluation platform in mice demonstrates that sequence variation in human RABEP2 modulates ischemic stroke outcomes.”  Am J Hum Genet., 2022 Oct;109(10):1814-1827. PMID: 36167069

1. 4. Leehyeon Kim, Byung-Gil Lee, Minki Kim, Min Kyung Kim, Do Hoon Kwon, Hyunmin Kim, Heike Brötz-Oesterhelt, Soung-Hun Roh, Hyun Kyu Song, “Structural insights into ClpP protease side exit pore-opening by a pH drop coupled with substrate hydrolysis.”  EMBO J., 2022 Jul;41(13): e109755. PMID: 35593068

1. 5. Leehyeon Kim, Jiwon Heo, Do Hoon Kwon, Jin Seok Shin, Se Hwan Jang, Zee-Yong Park, Hyun Kyu Song, “Structural basis for the N-degron specificity of ClpS1 from Arabidopsis thaliana.”  Protein Sci., 2021 Mar;30(3): 700-708. PMID: 33368743

1. 6. Yeongju Lee, Jiwon Heo, Hoibin Jeong, Kyung Tae Hong, Do Hoon Kwon, Min Hyeon Shin, Misook Oh, Ganesh A Sable, G-One Ahn, Jun-Seok Lee, Hyun Kyu Song, Hyun-Suk Lim, “Targeted Degradation of Transcription Coactivator SRC-1 through the N-Degron Pathway.” Angew Chem Int Ed Engl., 2020 Sep;59(40):17548-17555. PMID: 33026161
      
      

   7. Leehyeon Kim‡, Do Hoon Kwon‡, Jiwon Heo, Mi Rae Park, Hyun Kyu Song, “Use of the LC3B-fusion technique for biochemical and structural studies of proteins involved in the N-degron pathway.” J. Biol. Chem., 2020 Feb;295(9):2590-2600. PMID: 31919097

1. 8. Ok Hyun Park, Hongseok Ha, Yujin Lee, Sung Ho Boo, Do Hoon Kwon, Hyun Kyu Song, Yoon Ki Kim, “Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex.” Mol. Cell., 2019 May;74(3):494-507. PMID: 30930054

1. 9. Incheol Ryu, You-Sub Won, Hongseok Ha, Eunjin Kim, Yeonkyoung Park, Min Kyung Kim, Do Hoon Kwon, Junho Choe, Hyun Kyu Song, Hosung Jung, Yoon Ki Kim, “eIF4A3 Phosphorylation by CDKs Affects NMD during the Cell Cycle.” Cell Rep., 2019 Feb;26(8):2126-2139. PMID: 30784594
      
      

   10. Do Hoon Kwon, Leehyeon Kim, Hyun Kyu Song, “pH-dependent regulation of SQSTM1/p62 during autophagy” Autophagy, 2019 Jan;15(1):180-181 PMID: 30290711 (commentary)
       
       

   11. Leehyeon Kim, Do Hoon Kwon, Bong Heon Kim, Jiyeon Kim, Mi Rae Park, Zee-Yong Park, Hyun Kyu Song, “Structural and Biochemical Study of the Mono-ADP-Ribosyltransferase Domain of SdeA, a Ubiquitylating/Deubiquitylating Enzyme from Legionella pneumophila.”
       J Mol Biol., 2018 Aug;430(17):2843-2856. PMID: 29870726
       
       

   12. Sook Ho Kim, So-Hee Lim, Ae-Ree Lee, Do Hoon Kwon, Hyun Kyu Song, Joon-Hwa Lee, Minhaeng Cho, Albert Johner, Nam-Kyung Lee, Seok-Cheol Hong, “Unveiling the pathway to Z-DNA in the protein-induced B-Z transition.” Nucleic Acids Res., 2018 May;46(8):4129-4137. PMID: 29584891
       
       

   13. Do Hoon Kwon, Hyun Kyu Song, “A Structural View of Xenophagy, a Battle between Host and Microbes” Mol. Cells., 2018 Jan;41(1):27-34 PMID: 29370690 (review article)
       
       

   14. Do Hoon Kwon, Leehyeon Kim, Byeong-Won Kim, Jun Hoe Kim, Kyung-Hye Roh, Eui-Ju Choi, Hyun Kyu Song, “A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ.” Biochem. Biophys. Res., 2017 Aug;490(3):1093-1099. PMID: 28668392

1. 15. Ah-Reum Han, Hye-Ri Kang, Jonghyeon Son, Do Hoon Kwon, Sulhee Kim, Woo Cheol Lee, Hyun Kyu Song, Moon Jung Song, Kwang Yeon Hwang, “The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism.” Nucleic Acids Res., 2016 Nov;44(19):9483-9493. PMID: 27596595
       
       

   16. Byeong-Won Kim, Do Hoon Kwon, Hyun Kyu Song, “Structure biology of selective autophagy receptors.” BMB Rep., 2016 Feb;49(2):73-80. PMID: 26698872

1. 17. Byeong-Won Kim, Seung Beom Hong, Jun Hoe Kim, Do Hoon Kwon, Hyun Kyu Song, “The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism.” Nat. Commun., 2013:4:1613. PMID: 23511477