We aim to understand the fundamental principles of life at the molecular level and to apply this knowledge to the development of novel therapeutics for various diseases. In particular, our research focuses on elucidating the structures and functions of membrane proteins, such as cell membrane receptors and ion channels. By employing state-of-the-art techniques in structural biology and biochemistry, we investigate protein–protein interactions and the mechanisms of signal transduction.

  Cells must sense changes in their external environment and respond appropriately in order to survive. At the heart of this process are membrane receptors and channels, which transmit signals across the cell membrane. Our laboratory is dedicated to uncovering how the recognition of external signals at the cell surface occurs at the molecular level. Through this research, we aim to deepen our understanding of information transfer in biological systems and to identify the structural features of disease-related proteins, ultimately contributing to the development of new therapeutic strategies.

  Guided by the philosophy that “seeing is believing,” our core mission is to determine the atomic-level structures of proteins. To achieve this, we utilize cryo-electron microscopy (cryo-EM) to analyze the three-dimensional structures of biomolecules. These structural studies enable us to understand the physical principles of protein–protein interactions and to generate new hypotheses that explain biological functions. Furthermore, by leveraging structural insights into biomolecules, we contribute to drug discovery efforts. In particular, we employ structure-based drug design approaches to analyze the crystal structures of target proteins and to identify potential therapeutic candidates.

  We welcome inquiries from motivated students who share our passion for exploring the molecular basis of life and advancing the frontiers of biomedical research!